5th International Meeting of Gene Therapy of Arthritis and Related Disorders

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Scientific Program E-mail
 Scientific Program
 Tuesday Evening, April 29, 2008
  
5:00-6:30Poster Set-Up
6:30-7:30Welcoming Reception
7:30-8:30Keynote Address: Next generation protein therapeutics for
autoimmune diseases and oncology
 Kendall Mohler, Senior Vice President of R&D
 Trubion Pharmaceuticals
                                                                               
 Wednesday, April 30, 2008
  
7:00-8:00Continental breakfast
 Session 1: Advances in Gene Transfer
 (Chair: Steve Ghivizzani)
 8.15-8.40Jeff Bartlett:Defining and modifying cellular responses to AAV vector
administration
 8.40-9.05Anahita Keravala:Direct DNA delivery and stem cell approaches Using PhiC31 Integrase for arthritis
 9.05-9.25Florence Apparailly :New RNAi-based vector for validationof new therapeutic targets in arthritis
 9.25-9.45Margriet Vervoordeldonk: AAV-mediated gene transfer for arthritis
 9.45-10.05 Jay Chiorini:Sjögren’s Syndrome in models of autoimmunity

  
10:05-10:30Coffee Break and Poster Viewing
 Session 2: Gene, Cell and Biological Approaches for Arthritis
 (Chair: Florence Apparailly)
 10.30-10.55Michael Brenner:Role of synovial fibroblasts and cadherin-11 in rheumatoid arthritis
 10.55-11.20Ming Pei: Synovium-derived stem cell-based cartilage tissue engineering for cartilage repair

 

 11.20-11.45Harris Perlman: Therapeuticpotential of BH3 mimetics in treating autoimmune disease:
 11.45-12.10John Simms:IL-1 Inhibition in Osteoarthritis:  Size Matters
  
12:10-1:45Lunch
 Session 3: Gene, Cell and Biological Approaches for Immunomodulation
 (Chair: Paul Robbins)
 1.45-2.10Alexander Rudensky: Regulatory T cell mediated control of infection and autoimmunity
 2.10-2.35Steve Wiley:Leveraging viral evolution to create novel therapeutics for autoimmune and inflammatory diseases
 2.35-3.00Gary Fathman:Using gene arrays to define targets for adoptive cellular gene therapy
 3.00-3.25Yuti Chernajovsky:Novel targetted therapies for the treatment of autoimmune diseases
  
3:25-4:00Coffee Break and Poster Viewing
 Session 4: Gene, cell and biological approaches for bone and cartilage
 (Chair: Edward Schwarz)
 4.00-4.20Bill Dougall: Role of the TNF ligand superfamily member RANKL in inflammatory bone disease
 4.20-4.40Chisa Hidaka: Hedgehog signaling and trabecular architecture
 4.40-5.00Chris Niyibizi: Cell therapy approaches for osteogenesis imperfecta
 5.00-5.20

Manjula Viggeswarapu:Gene, cell and biological approaches for bone and cartilage : SPINAL DISORDERS

 5.20-5.40 Steve Ghivizzani: Gene Therapy for Achondroplasia.
  
7:00-10:00Gala Dinner
                                
 Thursday, May 1, 2008
  
7:00-8:00Continental Breakfast
 Session 5: Gene and Biological Therapies for Arthritis: Clinical Studies I
 (Chair: Haim Burstein)
 8.30-8.55Chris Evans: Getting local AAV.IL-1Ra therapy into the clinic
 8.55-9.20Paul-Peter Tak: Rheumatoid arthritis: Innovative trial design
 9.20-9.45Larry Moreland: Update on new and current therapies for rheumatoid arthritis
 9.45-10.10Phil Mease:I Intra-articular therapy for inflammatory arthritis using a recombinant AAV2 vector containing a TNFα antagonist gene
  
10.10-10.40Coffee Break and Poster Viewing
 Session 6: Gene and Biological Therapies for Arthritis: Clinical Studies II
 (Chair: Paul-Peter Tak)
 10.40-11.05Jerry Nepom: Autoimmune phenotyping for rational therapy
 11.05-11.30Tetsuya Tomita: Clinical application NFkappaB decoy deoxyoligonucleotides for rheumatoid arthritis
 11.30-11.55Peter Wehling: Human clinical experiences and studies using anti-inflammatory exosomes and Orthokine in auto immune and degenerative orthopaedic disease
 11.55-12.20Kwan H. Lee: Preclincal and early clinical analysis of allogeneic chondrocytes transfected retrovirally with TGF-beta1 gene for degenerative arthritis patients
  
12:20-1:30Lunch
 Session 7: Gene and Biological Therapies for Bone and Cartilage: Clinical Studies
 (Chair: Chris Evans)
 1.30-1.55Gloria Mathews: Local growth factor gene therapy for orthopaedic indications
 1.55-2.20Zulma Gazit: Mesenchymal stem cells: Immunoisolation and clinical application in skeletal regeneration
 2.20-2.45Debra Zack : Inflammatory arthritis; How well do rodents mimic the human disease? Studies with RANKL Inhibition
 2.45-3.10

Alan Nixon: Combinatorial RNA silencing approaches to gene enhanced cartilage repair

  
3.10-3.30 Coffee Break
3:30-4:30Session 8: Young Investigator Presentations (selected from abstract submissions)
 (Chair: Margriet Vervoordeldonk)
4:30-5:00Closing Remarks and Discussion
      
 
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